What is usually the first sign of anaphylactic shock?

The first sign of anaphylactic shock is typically difficulty breathing due to airway swelling. In anaphylactic reactions, the body releases an excessive amount of histamine and other chemicals in response to an allergen. This rapid response leads to symptoms such as bronchoconstriction and increased vascular permeability, both of which can cause the airway to swell, making it difficult for the individual to breathe. While other symptoms like rash, hypotension, and confusion may arise as the reaction progresses, respiratory distress is often the initial and most acute manifestation. Recognizing this sign is crucial for prompt intervention, as airway compromise can lead to life-threatening situations if not addressed quickly.